A REVIEW OF KETAMINE OVERDOSE WIKI

Metabolism Ketamine is metabolized by using N-dealkylation for the Energetic metabolite norketamine principally by CYP2B6 and CYP3A4 also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation on the cyclohexone ring to form hydroxynorketamine compounds by using CYP-dependent pathways, which are conjugated with glucuronic acid